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신장 이식 환자의 적혈구에서 산화적 손상

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Author(s)
정상호문교철
Keimyung Author(s)
Mun, Kyo Cheol
Department
Dept. of Biochemistry (생화학)
Journal Title
Keimyung Medical Journal
Issued Date
2000
Volume
19
Issue
1
Keyword
CatalaseGlutathione peroxidaseOxidative damageSuperoxide dismutase
Abstract
Patients with end stage renal failure display increased oxidative damage to red blood cell (RBC) membranes, characterized by elevated levels of malondialdehyde, a short chain aldehyde produced by the oxidation of the polyunsaturated fatty acids in the RBC membranes. This oxidative damage induces increased RBC rigidity and decreased RBC deformability, therefore favoring hemolysis in patients. The aim of this work was to determine whether renal graft would reduce the oxidative damage or not. Malondialdehyde and three well known antioxidant enzymes were measured in controls, and patients with renal graft or end stage renal disease. Malondialdehyde and glutathine peroxidase levels in patients with end stage renal disease were higher than those from ehalthy controls. Superoxide dismutase and catalase activities in patients with end stage renal disease were lower. These all parameters in the shortened(RBCs) from renal graft were normalized. These results indicate that a well-functioning renal graft restores the normal activities of antioxidant enzymes in RBCs, thus results in the elimination of the oxidative damage induced by uremia.
Alternative Title
Oxidative Damage in
Erythrocytes from Patients with Renal Transplant
Keimyung Author(s)(Kor)
문교철
Publisher
Keimyung University School of Medicine
Citation
정상호 and 문교철. (2000). 신장 이식 환자의 적혈구에서 산화적 손상. Keimyung Medical Journal, 19(1), 61–68.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15185
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2000
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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