14C-요소 호기검사를 이용한 Helicobacter pylori의 3제요법과 2제요법의 제균율 분석

Abstract

Helicobacter pylori (H. pylori) infection is associated with chronic active gastritis, duodenal and gastric ulcers, gastric adenocarcinoma, and gastric lymphoma. The eradication of H. pylori not only results in the healing of ulcer but also reduces recurrence of peptic ulcer. Using 14C-urea breath test, we compared the efficacy of omeprazole-based triple therapy and dual therapy in patients with H. pylori-positive peptic ulcer. Seventy nine H. pylori-positive patients with peptic ulcer were enrolled and randomly divided into two groups. Fifty nine patients received triple therapy (omeprazole, clarithromycin and amoxicillin) for 7 days and twenty patients received dual therapy (omeprazole and clarithromycin) for 14 days. The eradication of H. pylori was assessed by 14C-urea breath test 4-8 weeks after the completion of each therapy. The overall eradication rate of H. pylori, using 14C-urea breath test, was 88.1% in the triple therapy group and 35% in the dual therapy group, therefore the eradication rate of triple therapy was higher than that of dual therapy.