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간외성 담즙울체 쥐에서 간의 Epoxide Hydratase활성에 미치는 급성주정중독의 영향

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Author(s)
곽춘식최기석
Keimyung Author(s)
Kwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
Keimyung Medical Journal
Issued Date
2003
Volume
22
Issue
2
Keyword
Alcohol intoxicationCholestasisEpoxide hydratase
Abstract
To elucidate the biochemical
background of alcohol drinking hazard under the hepatobiliary disease, hepatic epoxide hydratase activity was determined in acute ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation (CBD). Liver microsomal epoxide hydratase activity in CBD ligated rats combined with acute ethanol intoxication was lower than that in CBD ligation alone. On the other hand, the Vmax value of the enzyme in these rats was lower than that in CBD ligation alone, wheras the Km value of the above hepatic enzyme did not vary among all the experimental groups. This result indicates that biosynthesis of the hepatic epoxide hydratase decreases in acute ethanol intoxication combined with cholestasis than in cholestasis alone. Accordingly, the results support the observation that alcoholic drink is enzymologically harmful in hepatobiliary diseases.
Alternative Title
Effect of Acute
Ethanol Intoxication on Hepatic Epoxide Hydratase
Activity in Rats with Extrahepatic Cholestasis
Keimyung Author(s)(Kor)
곽춘식
Publisher
Keimyung University School of Medicine
Citation
곽춘식 and 최기석. (2003). 간외성 담즙울체 쥐에서 간의 Epoxide Hydratase활성에 미치는 급성주정중독의 영향. Keimyung Medical Journal, 22(2), 178–185.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15279
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2003
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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