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폐경후 여성에서 여성호르몬과 알렌드로네이트 치료약제에 따른 골밀도와 골대사 표지물질의 변화

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Author(s)
박동희김의현김원호김성재김희경이상원이인규
Keimyung Author(s)
Lee, In Kyu
Department
Dept. of Internal Medicine (내과학)
Journal Title
Keimyung Medical Journal
Issued Date
2003
Volume
22
Issue
2
Keyword
AlendronateBiochemical markerHormone replacement therapyOsteoporosis
Abstract
The aim of this study was to
investigate the effect of different classes of drugs, which are currently available for the treatment of osteoporosis. Forty nine postmenopausal women with osteoporosis participated in this study. Subjects were divided into IV groups: Group I was treated with activated vitamin D, Group II with estrogen, Group III with alendronate, and Group IV with estrogen and alendronate. Treatment duration was one year. The levels of serum calcium, phosphorous and alkaline phosphate (ALP) and urine deoxypyridinoline(DPD), osteocalcin and bone mineral densities (BMD) were determined before and after the treatment. The total serum ALP and osteocalcin were significantly decreased, and BMD was significantly increased in Group IV. However, significant difference in the markers to indicate bone metabolism was not found among Group I, II and III. The present study showed the combination therapy of alendronate and estrogen to be the most effective in improving BMD and tone chemical marker.
Alternative Title
Changes of BMD
and Bone Turnover Marker after Estrogen and Alendronate Therapy in Postmenopausal Women with Osteoporosis
Keimyung Author(s)(Kor)
이인규
Publisher
Keimyung University School of Medicine
Citation
박동희 et al. (2003). 폐경후 여성에서 여성호르몬과 알렌드로네이트 치료약제에 따른 골밀도와 골대사 표지물질의 변화. Keimyung Medical Journal, 22(2), 236–342.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15285
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2003
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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