Sibutramien을 투여한 비만 환자에서 심박동수 변이의 단기변화

Abstract

The purpose of this study was to investigate the short term effect of sibutramine on heart rate variability (HRV) in obese subjects. 12 obese subjects were recruited from obesity clinic of Dongsan Medical Center in Deagu, Korea. They were divided two groups, which were sibutramine group(n=6) and non-sibutrmine group(n=6). HRV were evaluated when subject visited clinic, baseline and 2nd week. MHR, SDNN, RMSSD, TP, VLF, LF, HF, and LF-HF ratio were used as the indices of HRV. In sibutramine group, body weight, BMI, and WHR after 2 week were significantly decreased (P<0.05), but, all of parameters of HRV were not significantly changed. In non-sibutramine group, SDNN was significantly decreased after 2 weeks (P<0.05), but other parameters and anthropometric data were not different. Comparisons of Differences of parameters of HRV in before and after between groups were statistically not significant. We suggest the use of sibutramine in obese subject may do not have short term adverse effect against autonomic nervous system. But, the further evaluation about effect of sibutramine against autonomic nervous system in obese subject is needed more larger sample size and long term follow up.