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총담관 대정맥문합수술을 한 쥐에서 혈청과 간의 라이소좀 α-D-Glucosidase 및 β-D-Glucuronidase 활성도에 미치는 Taurocholic Acid의 정맥 내 투여의 효과

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Author(s)
김여희최혜정곽춘식
Keimyung Author(s)
Kim, You HeeKwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
Keimyung Medical Journal
Issued Date
2005
Volume
24
Issue
2
Keyword
α-D-Glucosidaseβ-D-Glucuronidase
Abstract
The effects of intravenous administration of high concentration of taurocholic acid (TCA) on α-D-glucosidase nad β-D-glucuronidase activities in rat liver lysosomes were studied. Above liver lysosomal enzymes, serum lysosmal α-D-Glucosidase and total β-D-Glucosidase activities were determined from the experimental rats with choledocho-caval shunt (CCS). The activities of liver lysosomal α-D-Glucosidase and β-D-Glucosidase as well as the activities of serum lysosomal α-D-Glucosidase and total β-D-Glucosidase were significantly increased in the CCS plus TCA injection group than in control group, such as group of CCS alone group. However, these hepatic and serum enzymes activities did not change in the CCS plus tauroursodeoxycholic acid injection group. The above results suggest that TCA stimulates the biosynthesis of the lysosomal α-D-Glucosidase and β-D-Glucosidase in the liver. And that the elevated lysosomal α-D-Glucosidase and total β-D-Glucosidase activities in the serum are most likely due to increased hepatocyte membrane permeability caused by TCA mediated liver cell necrosis.
Alternative Title
Effects of Intravenous Administration of Taurocholic Acid on
Lysosomal α-D-Glucosidase and β-D-Glucuronidase Activities
of Serum and Liver in Rats with Choledocho-Caval Shunt
Keimyung Author(s)(Kor)
김여희
곽춘식
Publisher
Keimyung University School of Medicine
Citation
김여희 et al. (2005). 총담관 대정맥문합수술을 한 쥐에서 혈청과 간의 라이소좀 α-D-Glucosidase 및 β-D-Glucuronidase 활성도에 미치는 Taurocholic Acid의 정맥 내 투여의 효과. Keimyung Medical Journal, 24(2), 156–165.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15352
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2005
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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