일과성 심근 허혈에 민감한 조기 표지자로서 Ischemic Modified Albumin의 역활

Abstract

Human albumin undergoes a significant reduction in its capacity to bind exogenous cobalt soon after transient coronary occlusion by percutaneous transluminal coronary angioplasty (PTCA). We investigated the changes of ischemic modified albumin(IMA) level following transient myocardial ischemia. We enrolled forty patients who diagnosed as chronic stable angina. These patients divided into 2 groups. Twenty seven patients who underwent PTCA were as group 1, 13 patients who underwent diagnostic coronary angiography as group 2. Venous samples were obtained 15 minutes, 1 hour, 6 hours and 12 hours after procedures. In group 1, the level of IMA was 97.7±15.4 U/mL at basal and 116.6±13.1 U/mL at 15 minutes, which was significantly increased than basal. In group 2, The IMA level was significantly increased from basal (96.0±6.8 U/mL) to 15 minutes (104.3±6.6 U/mL). The difference IMA levels was statistically significant (p<0.001) in both groups until 1 hour. The changes of the IMA can be an early sensitive marker of transient myocardial ischemia and may have a role in very early ischemic event.