신세포암의 세포유형 분류에 따른 생존율 비교

Abstract

In order to comprehend the characteristic relation between the survival rate and cell type of renal cell carcinomas, this study reclassified and reanalyzed the patients diagnosed as renal cell carcinoma in accordance with cell types. Among the 171 cases subject to radical nephrectomy due to renal tumor at Dongsan medical center of department of Urology from January 1993 to January 2005, this study selected 159 cases of renal cell carcinoma available for follow-up study and, in accordance with all types presented by UICC and AJCC in 1997 and taxonomy of papillary renal cell carcinoma developed by Delahunt et al in 1997. This study compare their survival rates, TNM stage, nuclear grade and micro-vascular invasion according to each cell type. During the follow-up period, one (25.0%) of 4 cases with clear cell type showing changes in sarcomatoid was died. Among 3 cases with papillary II type, 2 cases (66.7%) were died. Among the cases with clear cell type showing changes in sarcomatoid, however, each two cases were at stage 3 (50%) and 4 (50%) in their TNM stage, respectively, and all of them had type 4 of nuclear grade. For papillary II type, stage 4 of TNM stage ranked first (66.7%), and all of them had type 3 of nuclear grade. Micro-vascular invasion occurred at 8.8% of selected cases as a whole, while it was observed at 25.0% in clear cell type with the changes in sarcomatoid and 66.7% in papillary II type. The cases with papillary II type or with changed sarcomatoid, however, showed more progressed TNM stage, higher nuclear grade and higher micro-vascular invasion, which resulted in lower survival rate.