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Clinical reviews about Overall Incidence of Adverse Effects in Amiodarone Treatment

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Author(s)
Yun Kyeong ChoYoon Nyun KimSeong wook hanMin Jung KimHyun Tae KimIn Cheol KimDong Whan JunHyun Ok choChang Wook Parkhyung Seop KimChang Wook NamSeung Ho HurKwon Bae Kim
Keimyung Author(s)
Cho, Yun KyeongKim, Yoon NyunHan, Seong WookKim, In CheolKim, Hyung SeopNam, Chang WookHur, Seung HoKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Keimyung Medical Journal
Issued Date
2007
Volume
26
Issue
2
Keyword
Adverse effects AmiodaroneDosesDuration
Abstract
Amiodarone is a effective agent for the treatment of many cardiac rhythm disturbances, ranging from paroxysmal atrial fibrillation to intractable ventricular tachyarrhythmias. However, amiodarone causes variable adverse effects from minor to life
threatening. The aim of this study was to review general incidence of and associated factors with
the adverse effects of amiodarone medication. Eight hundred seventy six patients who had taken
amiodarone regularly over three months or who stopped medication due to any adverse effect between November 1996 and March 2005 at Keimyung University Dongsan medical center were included. Ninty six patients (11.0%) developed the amiodarone toxicity in any type. Among them, 60 patients showed hypothyroidism and held 62.5%. 10 patients showed pulmonary toxicity and held 10.4%, 20 patients and 20.8%, 6 patients and 6.3%. Patients with toxicity were older than patients without toxicity as 65.1±12.1 and 61.9±13.4 yr (p=0.026). Total dose and duration of amiodarone medication in the toxicity group were 1615.4±1414.6 gm and 734.9±677.1 days and
565.4±668.1 gm and 1249.7±1411.6 days in non-toxicity group respectively. The incidence of
amiodarone induced toxicity was generally lower than established reports. If we had done regular
protocol for checking up amiodarone adverse effects, we could detect amiodarone induced toxicity more exactly. It suggests that an incidence of amiodarone induced adverse effects can be lessened and the toxicity is prevented to some degree treating patients with amiodarone more carefully and performing a regular follow up protocol during medication.
Keimyung Author(s)(Kor)
조윤경
김윤년
한성욱
김인철
김형섭
남창욱
허승호
김권배
Publisher
Keimyung University School of Medicine
Citation
Yun Kyeong Cho et al. (2007). Clinical reviews about Overall Incidence of Adverse
Effects in Amiodarone Treatment. Keimyung Medical Journal, 26(2), 87–95.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15395
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2007
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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