Effect of Ezetimibe/Simvastatin and Atorvastatin with
Conventional Dose on Achieving Target Low Density
Lipoprotein Cholesterol Goal
- Author(s)
- Dong Hwan Jun; Seung Ho Hur; In Chul Kim; Hyun Tae Kim; Yun Kyeong Cho; Chang Wook Nam; Hyung Seop Kim; Seong Wook Han; Yoon Nyun Kim; Kwon Bae Kim
- Keimyung Author(s)
- Hur, Seung Ho; Kim, In Cheol; Cho, Yun Kyeong; Nam, Chang Wook; Kim, Hyung Seop; Han, Seong Wook; Kim, Yoon Nyun; Kim, Kwon Bae
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Keimyung Medical Journal
- Issued Date
- 2009
- Volume
- 28
- Issue
- 1
- Keyword
- Atorvastatin; Ezetimibe; Lipoprotein; Simvastatin
- Abstract
- Although recent lipid-lowering agents were effective in reducing low-density lipoprotein (LDL) cholesterol level, many patients treated with lipid-lowering therapy did not achieve target LDL cholesterol level, especially in very high risk hypercholesterolemic patients. The aim of this study is to evaluate the efficacy of ezetimibe/simvastatin and atorvastatin with conventional dose on reducing lipid levels and achieving target LDL cholesterol level in very high risk hypercholesterolemic patients. A total of 79 patients in very high risk hypercholesterolemia were enrolled in the study. Patients are randomly grouped in 2: Group 1, ezetimibe/simvastatin 10/20 mg/day and Group 2, atorvastatin 10 mg/day. Target level of LDL cholesterol was defined less than <70 mg/dl at follow-up. The follow-up plasma lipid data were obtained after 8 weeks of treatment. Baseline plasma lipid data were similar between the two groups. Achieving target LDL cholesterol level was observed in 64% of the Group 1 and 40% of Group 2 at 8-week follow-up (p<0.05). Compared with Group 2, Group 1 showed a significantly reduction in LDL cholesterol
and non-high density lipoprotein cholesterol and a trend toward to a greater reduction in total
cholesterol and apolipoprotein A-1. In patients with very high risk hypercholesterolemia, ezetimibe/simvastatin 10/20 mg was superior to atorvastatin 10 mg/day in attainment of target
LDL- cholesterol goal and in efficacy with other lipoprotein parameters.
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