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Effect of Ezetimibe/Simvastatin and Atorvastatin with Conventional Dose on Achieving Target Low Density Lipoprotein Cholesterol Goal

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Author(s)
Dong Hwan JunSeung Ho HurIn Chul KimHyun Tae KimYun Kyeong ChoChang Wook NamHyung Seop KimSeong Wook HanYoon Nyun KimKwon Bae Kim
Keimyung Author(s)
Hur, Seung HoKim, In CheolCho, Yun KyeongNam, Chang WookKim, Hyung SeopHan, Seong WookKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Keimyung Medical Journal
Issued Date
2009
Volume
28
Issue
1
Keyword
AtorvastatinEzetimibeLipoproteinSimvastatin
Abstract
Although recent lipid-lowering agents were effective in reducing low-density lipoprotein (LDL) cholesterol level, many patients treated with lipid-lowering therapy did not achieve target LDL cholesterol level, especially in very high risk hypercholesterolemic patients. The aim of this study is to evaluate the efficacy of ezetimibe/simvastatin and atorvastatin with conventional dose on reducing lipid levels and achieving target LDL cholesterol level in very high risk hypercholesterolemic patients. A total of 79 patients in very high risk hypercholesterolemia were enrolled in the study. Patients are randomly grouped in 2: Group 1, ezetimibe/simvastatin 10/20 mg/day and Group 2, atorvastatin 10 mg/day. Target level of LDL cholesterol was defined less than <70 mg/dl at follow-up. The follow-up plasma lipid data were obtained after 8 weeks of treatment. Baseline plasma lipid data were similar between the two groups. Achieving target LDL cholesterol level was observed in 64% of the Group 1 and 40% of Group 2 at 8-week follow-up (p<0.05). Compared with Group 2, Group 1 showed a significantly reduction in LDL cholesterol
and non-high density lipoprotein cholesterol and a trend toward to a greater reduction in total
cholesterol and apolipoprotein A-1. In patients with very high risk hypercholesterolemia, ezetimibe/simvastatin 10/20 mg was superior to atorvastatin 10 mg/day in attainment of target
LDL- cholesterol goal and in efficacy with other lipoprotein parameters.
Keimyung Author(s)(Kor)
허승호
김인철
조윤경
남창욱
김형섭
한성욱
김윤년
김권배
Publisher
Keimyung University School of Medicine
Citation
Dong Hwan Jun et al. (2009). Effect of Ezetimibe/Simvastatin and Atorvastatin with
Conventional Dose on Achieving Target Low Density
Lipoprotein Cholesterol Goal. Keimyung Medical Journal, 28(1), 8–16.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15422
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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