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말기신부전 환자에서 Cytokine 발현

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Author(s)
성정훈하은영김여희최혜정손정남황은아한승엽박성배김현철문교철
Keimyung Author(s)
Ha, Eun YoungKim, You HeeMun, Kyo CheolHwang, Eun AhHan, Seung YeupPark, Sung BaeKim, Hyun Chul
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Keimyung Medical Journal
Issued Date
2009
Volume
28
Issue
1
Keyword
Cytokine arrayDialysisEnd-stage renal disease
Abstract
Patients with end-stage renal disease (ESRD) present an extremely high mortality rate. The leading hypothesis to explain this high mortality risk is that ESRD patients are exposed to a number of traditional risk factors for cardiovascular disease including atherosclerosis which is known as an active inflammatory process. The inflammatory process is mediated by several mediators including cytokines. Among the several mediators, the cytokines have received particular attention in recent years. The purpose of this study is to profile the expression of cytokines related to atherosclerosis and inflammation in patients with ESRD, Cytokine antibody array was performed using serum from patients treating with hemodialysis and peritoneal dialysis. And microarray for 4,800 genes to detect gene expression was performed using ROS 17/2.8 cells incubated with 20 mmol/L cyanate. Intercellular adhesion molecule-1, interleukin 1 soluble receptor type 1, monocyte chemoattractant protein 1, macrophage-colony stimulating factor,
macrophage inflammatory protein, platelet-derived growth factor, RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), transforming growth factor beta 1, tumor necrosis factor alpha, eotaxin, interleukin-6 soluble receptor, interleukin 8, interleukin 10, interleukin 16, and tissue inhibitor of metalloproteinases-2 were increased in their expression in patients with ESRD. According to these results, cardiovascular complications may be related with the increased expression of the some cytokines.
Alternative Title
Cytokine Array in Patients with End-Stage Renal Disease
Keimyung Author(s)(Kor)
하은영
김여희
문교철
황은아
한승엽
박성배
김현철
Publisher
Keimyung University School of Medicine
Citation
성정훈 et al. (2009). 말기신부전 환자에서 Cytokine 발현. Keimyung Medical Journal, 28(1), 35–44.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15425
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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