말기신부전 환자에서 Cytokine 발현

Abstract

Patients with end-stage renal disease (ESRD) present an extremely high mortality rate. The leading hypothesis to explain this high mortality risk is that ESRD patients are exposed to a number of traditional risk factors for cardiovascular disease including atherosclerosis which is known as an active inflammatory process. The inflammatory process is mediated by several mediators including cytokines. Among the several mediators, the cytokines have received particular attention in recent years. The purpose of this study is to profile the expression of cytokines related to atherosclerosis and inflammation in patients with ESRD, Cytokine antibody array was performed using serum from patients treating with hemodialysis and peritoneal dialysis. And microarray for 4,800 genes to detect gene expression was performed using ROS 17/2.8 cells incubated with 20 mmol/L cyanate. Intercellular adhesion molecule-1, interleukin 1 soluble receptor type 1, monocyte chemoattractant protein 1, macrophage-colony stimulating factor, macrophage inflammatory protein, platelet-derived growth factor, RANTES (Regulated upon Activation, Normal T-cell Expressed and Secreted), transforming growth factor beta 1, tumor necrosis factor alpha, eotaxin, interleukin-6 soluble receptor, interleukin 8, interleukin 10, interleukin 16, and tissue inhibitor of metalloproteinases-2 were increased in their expression in patients with ESRD. According to these results, cardiovascular complications may be related with the increased expression of the some cytokines.