계명대학교 의학도서관 Repository

백혈병 세포주에서 Silibinin의 세포자멸사 유도 효과

Metadata Downloads
Author(s)
정희정백원기
Keimyung Author(s)
Baek, Won Ki
Department
Dept. of Microbiology (미생물학)
Journal Title
Keimyung Medical Journal
Issued Date
2009
Volume
28
Issue
1
Keyword
ApoptosisHL-60K562LeukemiaSilibinin.
Abstract
Silibinin is a polyphenolic flavonoid antioxidant isolated from the milk thistle and is
used clinically to treat certain liver diseases. Recently it has been reported that silibinin has
anticancer properties. However, the cellular and molecular mechanisms underlying silibinin
induced growth inhibition in cancer cells are not clearly understood. In this study, we have
investigated whether silibinin exerts anti-proliferative and apoptotic effects on HL-60 and K562
human leukemia cells. It was found that silibinin inhibits cell proliferation in a dose-dependent
manner inducing apoptotic cell death. These findings suggest that silibinin could be a candidate for
anti-leukemic drug.
Alternative Title
Silibinin induces apoptosis in HL-60 and K562 leukemia cells
Keimyung Author(s)(Kor)
백원기
Publisher
Keimyung University School of Medicine
Citation
정희정 and 백원기. (2009). 백혈병 세포주에서 Silibinin의 세포자멸사 유도 효과. Keimyung Medical Journal, 28(1), 45–52.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15426
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.