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Prognostic Significance of Hypermethylation and Expression of p16, p21, and p53 Genes in Diffuse Large B-cell Lymphoma

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Author(s)
Hye Ra JungSun Young KwonMi Sun ChoeYu Na KangSang Pyo KimKun Young KwonSang Sook Lee
Keimyung Author(s)
Jung, Hye RaKwon, Sun YoungChoe, Mi SunKang, Yu NaKim, Sang PyoKwon, Kun YoungLee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Keimyung Medical Journal
Issued Date
2009
Volume
28
Issue
2
Keyword
Large B-cellLymphomaMethylationPrognosisP16P21P53
Abstract
Diffuse large B-cell lymphoma (DLBCL) accounts for approximately 30—40% of non-Hodgkin's lymphomas. Significant molecular prognostic markers of DLBCL are not well known. In this study, hypermethylation of p16, p21 and p53 gene and protein expression of p16, p21, and p53 in DLBCL were investigated with 91 paraffin blocks. Hypermethylation of p16 gene was more common than hypermethylation of p21 or p53 in DLBCL. Hypermethylation of p21 gene was highly related to recurrence and reduced expression of p21 protein showed a strong tendency of poor survival. For an individual patient with DLBCL, if the tumor shows hypermethylation of p21 gene, it may make to predict the increased risk of recurrence. If the
tumor shows reduced p16 expression, and/or methylation of p53 gene, it is important to consider
that this markers are related to higher international prognostic index, which help to predict
outcome of patients.
Keimyung Author(s)(Kor)
정혜라
권선영
최미선
강유나
김상표
권건영
이상숙
Publisher
Keimyung University School of Medicine
Citation
Hye Ra Jung et al. (2009). Prognostic Significance of Hypermethylation and
Expression of p16, p21, and p53 Genes in Diffuse Large B-cell Lymphoma. Keimyung Medical Journal, 28(2), 144–154.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15439
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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