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조골세포에서 시안산에 의한 유전자 발현

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Author(s)
성정훈하은영손정남황은아박성배문교철
Keimyung Author(s)
Ha, Eun YoungMun, Kyo CheolHwang, Eun AhPark, Sung Bae
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Keimyung Medical Journal
Issued Date
2009
Volume
28
Issue
2
Keyword
CyanateEnd-stage renal diseaseMicroarrayOsteoblast
Abstract
Renal osteodystrophy(ROD) contributes as a major long-term complication which is associated with high rate of morbidity. The factors contributing to ROD are still incompletely characterized. Cyanate, known as one of the uremic toxins, is derived spontaneously from urea. According to previous studies, cyanate appears to play a role as a trigger for apoptosis by activating proapoptotic signals in osteoblasts. The purpose of this study is to detect the gene expression by cyanate in osteoblasts. Microarray for 4,800 genes to detect gene expression was performed using ROS 17/2.8 cells incubated with 20 mmol/L cyanate. About twenty percent of the
genes among 4,800 genes were expressed by cyanate, and most of the expressed genes except the genes which are related stress were inhibited by cyanate. According to these results, cyanate may play a role in the pathogenesis of ROD due to plays as one of the stress factors and the inhibitor for gene expression in osteoblasts.
Alternative Title
Gene Expression by Cyanate in the Osteoblasts
Keimyung Author(s)(Kor)
하은영
문교철
황은아
박성배
Publisher
Keimyung University School of Medicine
Citation
성정훈 et al. (2009). 조골세포에서 시안산에 의한 유전자 발현. Keimyung Medical Journal, 28(2), 217–224.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15447
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2009
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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