염증성 섬유양 용종의 면역조직화학적 특징

Abstract

Inflammatory fibroid polyps (IFPs) are rare mesenchymal tumors of the gastrointestinal tract. IFPs occur mainly in the distal stomach or pylorus, and less frequently in the small intestine, colon, and esophagus. Microscopically IFPs are composed of spindle-shaped stromal cells, abundant small-sized blood vessels, and an inflammatory infiltrate dominated by eosinophils. The etiology and histogenesis of IFPs are unknown. Whether IFPs are neoplastic or reactive process is also unclear. Furthermore, morphologically IFPs can be mistaken for various lesions, from granulation tissue to high-grade sarcoma. We review IFPs to characterize clinical, histologic, and immunohistochemical features for c-kit and CD34. We collected 28 cases of gastrointestinal polyps, including 19 IFPs, 7 hyperplastic polyps and 2 juvenile polyps occur in stomach (n=18), small intestine (n=2), and colon (n=8). IFPs occurred in both sexes (male, 10; female, 9) over a broad age range (18-75 years). All IFPs, except ileal IFP, were positive reaction for CD34 and negative for c-kit. All hyperplastic polyps show negative for CD34 and positive for c-kit. But 2 juvenile polyps including an ileal IFP were all negative reaction for CD34 and c-kit. So, the diagnosis of IFP will be easy by the immunohistochemical stains for CD34 and c-kit even in the limited specimen lack of characteristics of IFP.