와르틴 종양과 유사한 갑상선 유두상 암종: 증례 보고

Abstract

Warthin-like tumor variant of thyroid papillary carcinoma is an uncommon variant. We report a case of Warthin-like tumor variant of thyroid papillary carcinoma in the thyroid gland of a 53-year-old woman. A 1.7 cm sized tumor was detected by screening ultrasound sonogrphy and confirmed by a fine needle aspiration cytology (FNAC). FNAC showed highly malignant cells and she underwent total thyroidectomy. Gross finding of the removed tumor showed a welldemarcated, pale brown, solid and firm appearance, measuring approximately 1.7 x 1.6 x 1.0 cm in size. Microscopically, the tumor mass was composed of papillary growth of atypical oncocytic epithelial cells in the center of tumor mass. The atypical oncocytic epithelial cells had groundglass nuclei with nuclear grooves and intranuclear cytoplasmic inclusion bodies. They were mixed with lymphoid tissue without lymphoid follicle with germinal center at the periphery of tumor mass. The surrounding parenchyme of thyroid gland has no lymphocytic infiltration. Histologic features of warthin-like variant of thyroid papillary carcinoma are distinct and well recognized. Here we report this case, with a review of papers.