갑상샘 저분화 섬암종의 세포학적 소견 - 1례 보고

Abstract

Poorly differentiated thyroid carcinoma (PDTC) is an uncommon and aggressive malignancy. Despite of the significant clinical implications of a diagnosis of PDTC, its cytomorphologic features have not been well defined. We report a case of a poorly differentiated “insular”carcinoma of the thyroid gland. The patient was a 48 yr old woman, who had left partial thyroidectomy twenty years ago. Two years ago, right thyroid mass was detected by ultrasonography. At that time, the thyroid function was normal. After fine needle aspiration, total thyroidectomy was done. Aspiration cytology of thyroid mass demonstrated trabecular and solid growth patterns, merging with follicular areas, absence of pleomorphism in the tumor cells even though hypercellularity, low grade of atypia, high nuclear/cytoplasmic ratio, and severe crowding clusters. Grooving of the nuclear surface might be appeared. So, cytologic features of papillary carcinoma should be differentiated and preoperative diagnosis suggestive of poorly differentiated “insular”carcinoma might be of value for planning surgical treatment and subsequent therapy.