신세포암에서 예후 인자로 혈소판 증가증, 적혈구침강속도 및 C반응단백의 비교

Abstract

The purpose of this study was to assess relationship between the prognosis of patients and the degree of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and thrombocytosis on the patients who underwent radical nephrectomy. The subject of study was 65 patients who underwent radical nephrectomy with Renal cell carcinoma (RCC) and whose level of ESR, CRP and thrombocytosis were measured at the time of making diagnosis. The study was conducted by classifying above ESR 20 mm/hr, CRP 0.5 mg/dL and thrombocytosis 350,000/uL as "increased group" and below these as "normal group". The tumor size, cellular type, pathologic stage, nuclear grade and distant metastasis were compared between two groups. The thrombocytosis and ESR were not found significant as prognostic factors in the multivariate analysis, but CRP was associated with cellular type (p=0.022), high degree of nuclear grade (p=0.006) and distant metastasis (p=0.001) and also was a significantly independent prognosis factor (p=0.020) in the multivariate analysis. In conclusion, the measurement of CRP at the time of making diagnosis will be very helpful for the estimation of prognosis in patients with RCC.