한국 정상인에서 우유 불내성 증상은 유당수소호기 검사 양성과 연관성이 있는가?

Abstract

Objective : Lactose intolerance is caused by the deficiency of lactase in the small intestine and frequency is about 84% in Korean. This study was undertaken to determine the relationship between lactose hydrogen breath test and history of milk intolerance. Method : We evaluated 311 healthy subjects who had not received antibiotics therapy within the previous 3 weeks. Lactose hydrogen breath test performed during 3 hours after oral 25 g lactose load. We asked them history of milk intolerance and gastrointestinal symptoms during test; abdominal pain, diarrhea, borborygmus and flatus. Result : One hundred ninety two of the 311 (61.7%) had positive lactose hydrogen breath test. One hundred fourty one subjects with a history of milk intolerance had positive result and 129 subjects with gastrointestinal symptoms during test among 192 subjects. There are relationship between lactose hydrogen breath test and gastrointestinal symptoms during test (p=0.026, r=0.126). There was no significant relationship between positive lactose hydrogen breath test and history of milk intolerance (p=0.184, r=0.075). Conclusion : Positive lactose hydrogen breath test and milk intolerance did not show a positive correlation. This is thought to be related to lactose adapation due to increased milk intake and additionalresearch is needed.