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Klebsiella pneumoniae의 항균제 감수성과 다약제 내성

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Author(s)
서성일백원기서민호
Keimyung Author(s)
Suh, Seong IlBaek, Won KiSuh, Min Ho
Department
Dept. of Microbiology (미생물학)
Institute for Medical Science (의과학연구소)
Journal Title
Keimyung Medical Journal
Issued Date
2012
Volume
31
Issue
1
Keyword
Antimicrobial susceptibilityCefepimeCeftazidimeESBLImipenemLevofloxacinMeropenemMultidrug resistant Klebsiella pneumoniae (MDRKP)Prevalence
Abstract
Klebsiella pneumoniae is one of the main causes of nosocomial infections. A total of 102 Klebsiella pneumoniae isolated from various clinical specimens in a university medical center were tested for antimicrobial drug susceptibility to 23 drugs including ceftazidime, cefepime, imipenem, meropenem and levofloxacin. Klebsiella pneumoniae were most frequently isolated from sputum (46.1%), followed by urine (24.5%), blood (13.7%), wound discharges (5.9%) and etc. All the strains were susceptible to meropenem and its MIC90 was 2 ㎍/mL. Only 3.9% and 6.9% of the strains were resistant to imipenem and cefepime, and their MIC90 were 2 ㎍/mL, 16 ㎍/mL, respectively. The resistance frequencies of doxycycline and tetracycline were 16.7%, and the MIC90 of doxycycline was 32 ㎍/mL. The resistance frequencies of amoxicillin-clavulanic acid, cefoxitin, cefoperazone, ceftazidime, ceftriaxone, aztreonam, netilmicin, amikacin, gentamicin tobramycin, levofloxacin, ofloxacin, ciprofloxacin, trimethoprim-sulfamethoxazole and chloramphenicol were 21.6-42.2%, and their MIC90s were 64 ㎍/mL to more than 512 ㎍/mL. All of the strains were
resistant to ampicillin and 63.7% of the strains were resistant to piperacillin. Isolation frequency
of multidrug resistant Klebsiella pneumoniae (MDRKP) strains was 30.4% (31 strains), which showed that MDRKP is prevalent. All the MDRKP were multiply resistant to more than 10 drugs. Two (2%) strains of Klebsiella pneumoniae were multiply resistant to 21 drugs. Among 31 MDRKP isolates, isolation frequency of extended-spectrum ß-lactamase (ESBL) phenotype
expressing strains were 87.1% (27 strains), which showed ESBL producing Klebsiella pneumoniae is highly prevalent. Continued surveillance of MDRKP-ESBL prevalence and antimicrobial resistance patterns should provide information that is important for initiation of appropriate antibacterial therapy of MDRKP infections.
Alternative Title
Antimicrobial Drug Susceptibility and Multidrug Resistance of Klebsiella pneumoniae
Keimyung Author(s)(Kor)
서성일
백원기
서민호
Publisher
Keimyung University School of Medicine
Citation
서성일 et al. (2012). Klebsiella pneumoniae의 항균제 감수성과 다약제 내성. Keimyung Medical Journal, 31(1), 63–73.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15555
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2012
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
3. Research Institutues (연구소) > Institute for Medical Science (의과학연구소)
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