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The Dysregulation of MicroRNA Machinery Components in Papillary Thyroid Cancer

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Author(s)
Shin Kim
Keimyung Author(s)
Kim, Shin
Department
Dept. of Immunology (면역학)
Institute for Cancer Research (암연구소)
Journal Title
Keimyung Medical Journal
Issued Date
2013
Volume
32
Issue
1
Keyword
AGO2DGCR8DroshaMicroRNA biogenesisPapillary thyroid cancer
Abstract
Although various research papers have revealed that alterations of microRNAs (miRNAs) expression profiles in thyroid cancer, there have been few studies on the miRNA machinery itself. Altered expression of microRNA (miRNA) machinery components may play an important role in progression of thyroid cancer. The purposes of this study were to evaluate the mRNA expression levels of important miRNA machinery components in papillary thyroid cancer (PTC) and to investigate the correlations between each component. By using quantitative real-time PCR, the mRNA expressions of the four miRNA machinery components were examined in 40 PTC tissues and their adjacent non-neoplastic tissues. In the present study, decreased mRNA expression level of Drosha was observed in PTC. The altered mRNA expression levels of Dicer and AGO2; DGCR8 and Drosha; AGO2 and DGCR8 were positively correlated with each other. This study revealed for the first time that altered expression of Drosha is present in PTC tissue and could be potentially responsible for altered miRNAs profiles observed in this malignancy.
Keimyung Author(s)(Kor)
김신
Publisher
Keimyung University School of Medicine
Citation
Shin Kim. (2013). The Dysregulation of MicroRNA Machinery Components in Papillary Thyroid Cancer. Keimyung Medical Journal, 32(1), 29–35.
Type
Article
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15592
Appears in Collections:
2. Keimyung Medical Journal (계명의대 학술지) > 2013
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
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