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Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm

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Author(s)
Ji Hyun NohYong Hoon KimKoo Jeong KangTae-Seok KimKeun Soo Ahn
Keimyung Author(s)
Kim, Yong HoonKim, Tae SeokAhn, Keun SooKang, Koo Jeong
Department
Dept. of Surgery (외과학)
Journal Title
Annals of Surgical Treatment and Research
Issued Date
2016
Volume
91
Issue
3
Keyword
Hepatocellular carcinomaHepatectomyPrognosis
Abstract
periPurpose:
This study aimed to determine which factors affect the prognosis of hepatectomy for hepatocellular carcinoma
(HCC) larger than 5 cm, including the prognostic difference between tumor sizes from 5–10 cm and larger than 10 cm.
Methods: The medical records of 114 patients who underwent hepatectomy for single HCC larger than 5 cm were reviewed
and analyzed retrospectively.
Results: In the analysis of the entire cohort of 114 patients, the 5-year overall and diseases-free survival rates were 50%
and 29%, respectively. In a comparison of survival rates between groups, tumor sizes of 5 to 10 cm and larger than 10
cm, the overall and disease-free survival rates were not significantly different, respectively (54% vs. 41%, P = 0.433 and
33% vs. 23%, P = 0.083). On multivariate analysis, positive hepatitis B, high prothrombin induced by vitamin K absence
or antagonist-II levels over 200 mIU/mL, and vascular invasion (micro- and macrovascular invasion) were independent
prognostic factors for recurrence after hepatic resection. However, tumor size larger than 10 cm was not significant for
recurrence after resection.
Conclusion: This study shows that surgical resection of solitary HCC larger than 5 cm showed favorable overall survival.
And there is no survival difference with tumors between 5–10 cm and larger than 10 cm.
Keimyung Author(s)(Kor)
김태석
안근수
강구정
김용훈
Publisher
School of Medicine
Citation
Ji Hyun Noh et al. (2016). Prognostic factors after hepatic resection for the single hepatocellular carcinoma larger than 5 cm. Annals of Surgical Treatment and Research, 91(3), 104–111. doi: 10.4174/astr.2016.91.3.104
Type
Article
ISSN
2288-6575
DOI
10.4174/astr.2016.91.3.104
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32353
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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