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Adenovirus-induced Hemophagocytic Lymphohistiocytosis in a Previously Healthy Boy: A Case Report and Literature Review

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Author(s)
Yo Han SeoYe Jee ShimHeung Sik KimHee Joung LeeDong-Seok JeonHo Joon Im
Keimyung Author(s)
Shim, Ye JeeKim, Heung SikLee, Hee JungJeon, Dong Seok
Department
Dept. of Pediatrics (소아청소년학)
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Radiology (영상의학)
Journal Title
Clinical Pediatric Hematology-Oncology
Issued Date
2016
Volume
23
Issue
2
Keyword
AdenovirusHemophagocytic lymphohistiocytosisImmunocompetentInfection-associated hemophagocytic syndrome
Abstract
A 3-year-old previously healthy boy was admitted because of a 1-week history of fever, abdominal pain, vomiting, and diarrhea. The initial laboratory tests showed hepatic dysfunction with disseminated intravascular coagulation. There was a large amount of pleural effusion, periportal edema, minimal ascites, and splenomegaly. He was initially managed with broad spectrum antibiotics with transfusion. Despite 2 days of treatment, the fever persisted and the results of the laboratory tests had worsened. Bacterial cultures from the blood, urine, pleural effusion, and ascites were all negative. He was finally diagnosed with hemophagocytic lymphohistiocytosis (HLH) based on the diagnostic criteria. Adenovirus was detected in the initial diarrhea and nasal swab specimens using polymerase chain reaction-based method. One year after chemotherapy with dexamethasone, cyclosporine, and etoposide, he is now healthy without evidence of disease recurrence. This is the first Korean case report of adenovirus-induced HLH in a previously healthy child.
Alternative Title
평소 건강하였던 소아에서 아데노바이러스 감염으로 유발된 혈구탐식성 림프조직구증: 증례 보고 및 문헌 고찰
Keimyung Author(s)(Kor)
심예지
김흥식
이희정
전동석
Publisher
School of Medicine
Citation
Yo Han Seo et al. (2016). Adenovirus-induced Hemophagocytic Lymphohistiocytosis in a Previously Healthy Boy: A Case Report and Literature Review. Clinical Pediatric Hematology-Oncology, 23(2), 179–183. doi: 10.15264/cpho.2016.23.2.179
Type
Article
ISSN
2233-5250
DOI
10.15264/cpho.2016.23.2.179
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32388
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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