계명대학교 의학도서관 Repository

Transient elastography versus hepatic venous pressure gradient in diagnosing portal hypertension : a systematic review and meta-analysis

Metadata Downloads
Author(s)
Gaeun KimMoon Young KimSoon Koo Baik
Keimyung Author(s)
Kim, Ga Eun
Department
Dept. of Nursing (간호학)
Research Institute for Nursing Science (간호과학연구소)
Journal Title
Clinical and Molecular Hepatology
Issued Date
2017
Volume
23
Issue
1
Keyword
ElastographyHypertensionPortalLiver cirrhosisReviewSystematicMeta-analysis
Abstract
Background/Aims :

Transient elastography (TE) has been proposed as a promising noninvasive alternative to hepatic venous pressure gradient (HVPG) for detecting portal hypertension (PH). However, previous studies have yielded conflicting results. We gathered evidence from literature on the clinical usefulness of TE versus HVPG for assessing PH.


Methods :

We conducted a systematic review by searching databases for relevant literature evaluating the clinical usefulness of non-invasive TE for assessing PH in patients with cirrhosis. A literature search in Ovid Medline, EMBASE and the Cochrane Library was performed for all studies published prior to December 30, 2015.


Results :

Eight studies (1,356 patients) met our inclusion criteria. For the detection of PH (HVPG ≥6 mmHg), the summary sensitivity and specificity were 0.88 (95% confidence interval [CI] 0.86-0.90) and 0.74 (95% CI 0.67-0.81), respectively. Regarding clinically significant PH (HVPG ≥10 mmHg), the summary sensitivity and specificity were 0.85 (95% CI 0.63-0.97) and 0.71 (95% CI 0.50-0.93), respectively. The overall correlation estimate of TE and HVPG was large (0.75, 95% CI: 0.65; 0.82, P<0.0001).


Conclusions :

TE showed high accuracy and correlation for detecting the severity of PH. Therefore, TE shows promise as a reliable and non-invasive procedure for the evaluation of PH that should be integrated into clinical practice.
Keimyung Author(s)(Kor)
김가은
Publisher
College of Nursing
Citation
Gaeun Kim et al. (2017). Transient elastography versus hepatic venous pressure gradient in diagnosing portal hypertension : a systematic review and meta-analysis. Clinical and Molecular Hepatology, 23(1), 34–41. doi: 10.3350/cmh.2016.0059
Type
Article
ISSN
2287-2728
DOI
10.3350/cmh.2016.0059
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32394
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
3. Research Institutues (연구소) > Research Institute for Nursing Science (간호과학연구소)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.