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Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy

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Author(s)
Cheol Ryong KuNarae LeeJae Won HongIn Gyu KwonWoo Jin HyungSung Hoon NohMijin YunArthur ChoEun Jig Lee
Keimyung Author(s)
Kwon, In Gyu
Department
Dept. of Surgery (외과학)
Journal Title
Diabetes
Issued Date
2016
Volume
66
Issue
2
Abstract
Gastrectomy method is known to influence glucose homeostasis. 18F-fluorodeoxyglucose (FDG) PET/CT acquired after gastrectomy often reveals newly developed physiologic small bowel uptake. We correlated newly developed small bowel FDG uptake and glucose homeostasis in post-gastrectomy gastric cancer patients. We retrospectively analyzed 239 non-diabetic patients who underwent staging and follow-up FDG PET/CT before and after gastrectomy for gastric cancer. Post-operative small bowel glycolysis was quantified by recording intestinal total lesion glycolysis (TLG). TLG was assessed with regard to surgical method (Billroth I, II [BI, BII], Roux-en-Y [RY]), fasting glucose decrement (≥10 mg/dL), and other clinical factors. Patients’ weight, fasting glucose, cholesterol, TLG, and body fat significantly decreased after surgery. Glucose decrement was significantly associated with fasting glucose, surgical methods, total cholesterol, TLG, and total body fat on univariate analysis. Multivariate analysis showed that BII surgery (odds ratio: 6.51) and TLG (odds ratio: 3.17) were significantly correlated with glucose decrement. High small bowel glycolysis (TLG>42.0) correlated with glucose decrement in RY patients. Newly developed small bowel glycolysis on post-gastrectomy FDG PET/CT is correlated with glucose decrement. These findings suggest a potential role of FDG PET/CT in the evaluation of small bowel glycolysis and glucose control.
Keimyung Author(s)(Kor)
권인규
Publisher
School of Medicine
Citation
Cheol Ryong Ku et al. (2016). Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy. Diabetes, 66(2), 385–391. doi: 10.2337/db16-1000
Type
Article
ISSN
0012-1797
DOI
10.2337/db16-1000
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32395
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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