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Clinical characteristics of patients with adrenal insufficiency in a general hospital

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Author(s)
Ye Yeon LeeNan Hee ChoJong Won LeeNam Kyung KimHye Soon KimMi-Kyung Kim
Keimyung Author(s)
Kim, Hye SoonKim, Mi Kyung
Department
Dept. of Internal Medicine (내과학)
Journal Title
Endocrinology and Metabolism
Issued Date
2017
Volume
32
Issue
1
Keyword
Adrenal insufficiencyHypopituitarismPopulation characteristics
Abstract
Background : Adrenal insufficiency (AI) is a life-threatening disorder caused by the deficiency of adrenal steroid hormones. This retrospective cross-sectional study investigated the characteristics of patients with AI in Korea.
Methods : All consecutive patients with suspected AI who received care at a tertiary referral center in Korea in 2014 and underwent adrenocorticotropic hormone stimulation or insulin-tolerance testing were identified through a review of medical charts. Patients diagnosed with AI were enrolled. Their demographic, clinical, and treatment details were extracted.
Results : Of 771 patients with suspected AI, 183 (23.7%) received a definitive diagnosis. The most common reason for testing was the presence of suspicious AI-related symptoms (30.0%), followed by a history of steroid medications (23.5%). Their mean age was 66.7 years, and females predominated (67.8%). The most common symptoms were general weakness, anorexia, arthralgia, and fever. Approximately half (53.6%) had a history of steroid use. Hydrocortisone was the most common treatment (71.6%), with most patients taking a 30 mg dose (44.2%). The most common dose frequency was twice a day (78.6%). Fourteen patients were treated for adrenal crisis (n=10, 5.5%) or an intercurrent illness (n=4, 2.2%).
Conclusion : AI may have been caused by steroid medication use in many of the patients included in this study. The detection of AI can be improved by careful history-taking and being alert to the possibility that a patient has used steroids.
Keimyung Author(s)(Kor)
김미경
김혜순
Publisher
School of Medicine
Citation
Ye Yeon Lee et al. (2017). Clinical characteristics of patients with adrenal insufficiency in a general hospital. Endocrinology and Metabolism, 32(1), 83–89. doi: 10.3803/EnM.2017.32.1.83
Type
Article
ISSN
2093-596X
DOI
10.3803/EnM.2017.32.1.83
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32398
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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