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The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma

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Author(s)
Se Young JangSoo Young ParkHye Won LeeYeon-Kyung ChoiKeun-Gyu ParkGhil Suk YoonWon Young TakYoung Oh KweonKeun HurWon Kee Lee
Keimyung Author(s)
Lee, Hye Won
Department
Dept. of Pathology (병리학)
Journal Title
Gut and Liver
Issued Date
2016
Volume
10
Issue
6
Keyword
PeriostinMicrovascular invasionHepatocellular carcinomaTissue microarray analysisPrognosis
Abstract
Background/Aims : Periostin is an extracellular matrix protein and is known to be related to the metastatic potential and prognosis of cancer. However, few studies have investigated the expression level of periostin and its association with prognoses in hepatocellular carcinoma. Therefore, we analyzed periostin overexpression in hepatocellular carcinoma and its implication for prognoses.
Methods : We evaluated 149 patients who underwent surgical resection between 2006 and 2010. Tissue microarrays were constructed from hepatocellular carcinoma tissue and adjacent nontumor tissue, and immunohistochemistry was performed.
Results : A high periostin level was observed more frequently in cases of multiple tumors (odds ratio [OR], 2.826; 95% confidence interval [CI], 1.224 to 6.527; p=0.013), positive microvascular invasion (OR, 2.974; 95% CI, 1.431 to 6.181; p=0.003), and advanced stage disease (OR, 3.032; 95% CI, 1.424 to 6.452; p=0.003). Patients with high periostin expression had significantly (p=0.002) lower overall survival rates than those with low periostin expression (90.3%, 66.1%, and 56.2% vs 97.7%, 85.1%, and 77.5% at 1, 3, and 5 years).
Conclusions : We found that a combination of periostin overexpression and microvascular invasion in hepatocellular carcinoma was correlated with a poor prognosis and can be a good prognostic marker for hepatocellular carcinoma.
Keimyung Author(s)(Kor)
이혜원
Publisher
School of Medicine
Citation
Se Young Jang et al. (2016). The Combination of Periostin Overexpression and Microvascular Invasion Is Related to a Poor Prognosis for Hepatocellular Carcinoma. Gut and Liver, 10(6), 948–954. doi: 10.5009/gnl15481
Type
Article
ISSN
1976-2283
DOI
10.5009/gnl15481
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32411
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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