Implications of prescribing a fixed-dose combination in clinical cardiology practice: a retrospective observational study using a single medical centre database in Korea
- Author(s)
- Hyungseop Kim; Hyuck-Jun Yoon; Hyoung-Seob Park; Yun-Kyeong Cho; Chang-Wook Nam; Seongwook Han; Seung-Ho Hur; Yoon-Nyun Kim; Kwon-Bae Kim
- Keimyung Author(s)
- Kim, Yoon Nyun; Park, Hyoung Seob; Kim, Hyung Seop; Hur, Seung Ho; Yoon, Hyuck Jun; Nam, Chang Wook; Cho, Yun Kyeong; Han, Seong Wook; Kim, Kwon Bae
- Department
- Dept. of Internal Medicine (내과학)
- Journal Title
- Heart Asia
- Issued Date
- 2017
- Volume
- 9
- Issue
- 2
- Keyword
- Adherence; Fixed-dose combination; Prognosis.
- Abstract
- Objective Fixed-dose combination (FDC) prescribing
enhances adherence to medication. However, there
are limited data regarding the usefulness of FDC drugs
across different risk groups. The aim of this study was to
explore the relationship between FDC discontinuation
and clinical outcomes.
Methods From January 2008 to December 2014,
patients with FDC prescriptions who visited a cardiology
outpatient clinic at a tertiary university hospital in Daegu,
Republic of Korea were retrospectively identified. The
10-year atherosclerotic cardiovascular disease (ASCVD)
risk score and 20 conventional cardiovascular (CV) risk
factors were assessed. Patients were classified according
to FDC continuation, together with a tertile of 20 risks.
CV events were defined as the composite of admission
for worsening heart failure or diabetes, stroke, ischaemic
heart disease, and CV death.
Results 502 patients were prescribed with one of the
following FDC products: calcium channel blocker (CCB)
plus angiotensin receptor blockers (ARB), CCB plus
statins, and ARB plus diuretics. During follow-up (mean
2.8±2.4 years), 203 discontinuations (40.4%) occurred.
FDC-discontinued patients had lower ASCVD risk scores
(24.8% vs. 28.8%, p<0.001), and patients with <6 risk
factors discontinued FDC frequently. During follow-up,
57 events (11.4%) were reported: 30 (14.8%) in FDCdiscontinued
patients and 27 (9.1%) in FDC-continued
patients (p=0.062). In multivariate models accounting for
events, FDC discontinuation (p<0.001) and high ASCVD
risk score (p=0.017) were associated with CV events.
Conclusions FDC discontinuation was common among
patients attending the cardiology outpatient clinic. Our
analyses suggest that FDC discontinuation in patients at
high ASCVD risk may have an impact on CV event rates.
- Authorize & License
-
- Files in This Item:
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.