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Mitochondrial D-loop polymorphism in tubular adenomas and serrated polyps of colorectal lesions

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Author(s)
Jae-Ho LeeGi-Jeong GwonDae-Kwang Kim
Keimyung Author(s)
Kim, Dae KwangLee, Jae Ho
Department
Dept. of Anatomy (해부학)
Dept. of Medical Genetics (의학유전학)
Journal Title
International Journal of Clinical and Experimental Pathology
Issued Date
2017
Volume
10
Issue
2
Keyword
Colorectal cancermitochondriapolymorphismserrated polypstubular adenomas
Abstract
Colorectal cancer is a heterogeneous disorder than arises via multiple distinct pathways, from tubular adenomas (TAs) and serrated polyps (SPs), which are clinically, morphologically, and molecularly different. We examined mitochondrial D-loop polymorphism in colorectal precancerous lesions, including TAs and SPs. DNA was isolated from paired normal and tumoral tissues in 78 TAs and 34 SPs. Mitochondrial D-loop polymorphism (D146, D150, D152, D310, and D514), KRAS and BRAF mutations, and microsatellite instability (MSI) were analyzed by direct sequencing and pyrosequencing. D146, D310, and D514 were polymorphic in these patients and their distributions were significantly different between TAs and SPs. D146 and D310 polymorphism was associated not with KRAS and BRAF mutations, but with MSI and other mitochondrial polymorphism each other. Our data suggest that mitochondrial D-loop polymorphism may play an important role in development of colorectal precancerous lesions and contribute to regulate their progression to TAs or SPs.
Keimyung Author(s)(Kor)
김대광
이재호
Publisher
School of Medicine
Citation
Jae-Ho Lee et al. (2017). Mitochondrial D-loop polymorphism in tubular adenomas and serrated polyps of colorectal lesions. International Journal of Clinical and Experimental Pathology, 10(2), 1946–1953.
Type
Article
ISSN
1936-2625
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32418
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
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