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The effect of lowering target oxygen saturation on retinopathy of prematurity in neonatal respiratory distress syndrome

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Author(s)
Youhyun LeeSanglak LeeYu Cheol Kim
Keimyung Author(s)
Kim, Yu CheolLee, Sang Lak
Department
Dept. of Ophthalmology (안과학)
Dept. of Pediatrics (소아청소년학)
Journal Title
International Eye Science
Issued Date
2016
Volume
16
Issue
11
Keyword
Apgar scoreneonatal respiratory distress syndromeoxygenretinopathy of prematuritysurvival rate
Abstract
AIM: To determine the effect of lowered target oxygen
saturation levels on and identify risk factors of retinopathy
of prematurity ( ROP ) in neonatal respiratory distress
syndrome (RDS). METHODS: Medical records of consecutive preterm
infants (N = 252) diagnosed with RDS between Jan. 2009
and Dec. 2012 were retrospectively reviewed. The patients
were divided into higher - saturation (90 - 97% ; n = 116 ) and lower-saturation (85-93% ; n = 136) groups according
to their target oxygen saturation ranges. ROP severity
was assessed and relevant systemic parameters were
evaluated.
RESULTS: Incidence of ROP, need for laser ablation, and proportion of aggressive posterior ROP were not
significantly different between the groups, but the lowersaturation
group had a better survival rate (P = 0. 005).
Patients who spent an additional day in incubator care had
a 1. 041 times greater chance of developing ROP (odds
ratio = 1. 041; 95% CI = 1. 003-2. 275; P = 0. 002), whereas a
one- point increase in the 5min Apgar score reduced the
possibility by 24. 7% (odds ratio = 0. 753; 95% CI = 0. 152 -
0.965; P = 0. 033). CONCLUSION: Target oxygen saturation levels of 85%
to 93% may improve survival without affecting ROP
development in infants with RDS. The relevant risk factors
are duration of incubator care and 5-min Apgar score.
Keimyung Author(s)(Kor)
김유철
이상락
Publisher
School of Medicine
Citation
Youhyun Lee et al. (2016). The effect of lowering target oxygen saturation on retinopathy of prematurity in neonatal respiratory distress syndrome. International Eye Science, 16(11), 1992–1996. doi: 10. 3980/ j. issn. 1672-5123. 2016. 11. 03
Type
Article
ISSN
1672-5123
DOI
10. 3980/ j. issn. 1672-5123. 2016. 11. 03
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32420
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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