The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder
- Author(s)
- Je-Yeon Yuna; Jae-Chang Kim; Jeonghun Ku; Jung-Eun Shin; Jae-Jin Kim; Soo-Hee Choi
- Keimyung Author(s)
- Ku, Jeong Hun
- Department
- Dept. of Biomedical Engineering (의용공학과)
- Journal Title
- Journal of Affective Disorders
- Issued Date
- 2017
- Volume
- 214
- Keyword
- rs-FCN (resting state functional connectivity network); SAD (social anxiety disorder); HC (healthy controls); MTG (middle temporal gyrus)
- Abstract
- Background : Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD.
Methods : In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis.
Results : The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD.
Limitations : Most of participants included in this study were undergraduate students in their early-to-mid 20's.
Conclusions : This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.
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