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The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder

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Author(s)
Je-Yeon YunaJae-Chang KimJeonghun KuJung-Eun ShinJae-Jin KimSoo-Hee Choi
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Journal of Affective Disorders
Issued Date
2017
Volume
214
Keyword
rs-FCN (resting state functional connectivity network)SAD (social anxiety disorder)HC (healthy controls)MTG (middle temporal gyrus)
Abstract
Background : Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD.
Methods : In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis.
Results : The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD.
Limitations : Most of participants included in this study were undergraduate students in their early-to-mid 20's.
Conclusions : This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Je-Yeon Yuna et al. (2017). The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder. Journal of Affective Disorders, 214, 53–59. doi: 10.1016/j.jad.2017.01.043
Type
Article
ISSN
0165-0327
DOI
10.1016/j.jad.2017.01.043
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32440
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
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