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Estimating the Prevalence of Treated Epilepsy Using Administrative Health Data and Its Validity: ESSENCE Study

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Author(s)
Seo-Young LeeSoo-Eun ChungDong Wook KimSo-Hee EunHoon Chul KangYong Won ChoSang Do YiHeung Dong KimKi-Young JungHae-Kwan Cheong
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Neurology
Issued Date
2016
Volume
12
Issue
4
Keyword
epilepsyseizureprevalencehealth dataepidemiologyvalidation
Abstract
Background and Purpose:

Few of the epidemiologic studies of epilepsy have utilized well-validated nationwide databases. We estimated the nationwide prevalence of treated epilepsy based on a comprehensive medical payment database along with diagnostic validation.


Methods:

We collected data on patients prescribed of antiepileptic drugs (AEDs) from the Health Insurance Review and Assessment service, which covers the entire population of Korea. To assess the diagnostic validity, a medical records survey was conducted involving 6,774 patients prescribed AEDs from 43 institutions based on regional clusters and referral levels across the country. The prevalence of treated epilepsy was estimated by projecting the diagnostic validity on the number of patients prescribed AEDs.


Results:

The mean positive predictive value (PPV) for epilepsy was 0.810 for those prescribed AEDs with diagnostic codes that indicate epilepsy or seizure (Diagnosis-E), while it was 0.066 for those without Diagnosis-E. The PPV tended to decrease with age in both groups, with lower values seen in females. The prevalence was 3.84 per 1,000, and it was higher among males, children, and the elderly.


Conclusions:

The prevalence of epilepsy in Korea was comparable to that in other East Asian countries. The diagnostic validity of administrative health data varies depending on the method of case ascertainment, age, and sex. The prescriptions of AEDs even without relevant diagnostic codes should be considered as a tracer for epilepsy.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Seo-Young Lee et al. (2016). Estimating the Prevalence of Treated Epilepsy Using Administrative Health Data and Its Validity: ESSENCE Study. Journal of Clinical Neurology, 12(4), 434–440. doi: 10.3988/jcn.2016.12.4.434
Type
Article
ISSN
1738-6586
DOI
10.3988/jcn.2016.12.4.434
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32448
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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