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Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome

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Author(s)
Jung-won ShinYong Seo KooByeong Uk LeeWon Chul ShinSang Kun LeeYong Won ChoKi-Young Jung
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Clinical Sleep Medicine
Issued Date
2016
Volume
12
Issue
8
Keyword
restless legs syndromeperiodic limb movements in sleepperiodicity indexprevalencesleep quality
Abstract
Study Objectives:

The aim of this study was to investigate the prevalence and characteristics of periodic limb movements during sleep (PLMS) in Korean patients with restless legs syndrome (RLS).


Methods:

Unmedicated adult patients with idiopathic RLS (n = 354) who underwent polysomnography at three major sleep centers in tertiary hospitals were included. Characteristics of PLMS in RLS were analyzed using the time structure of polysomnographically recorded leg movements and periodicity indices (PIs). RLS severity and subjective sleep quality were assessed.


Results:

Out of 354 patients with idiopathic RLS (mean age: 52.9 ± 12.0 years), 150 patients (42.3%) had RLS with a PLMS index greater than 15 events/h, and 204 (57.9%) had a PLMS index greater than 5 events/h. The distribution of inter-LM intervals was bimodal, and high PIs (0.86 ± 0.10) were observed in patients with RLS and PLMS (PLMS index > 15 events/h). The PLMS index was positively correlated with age (r = 0.228; p < 0.001), the periodic limb movements in wakefulness index (r = 0.455, p < 0.001) and arousal index (r = 0.174, p = 0.014), but not with RLS severity and parameters of sleep quality. In multivariate analysis, age and male gender were independently associated with PLMS > 15 events/h.


Conclusions:

The prevalence of PLMS in Korean patients with RLS was lower than that observed in Western countries, but the characteristics of PLMS were not different. Ethnic differences and/or different genetic backgrounds may contribute to the varying prevalence of PLMS in RLS.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Jung-won Shin et al. (2016). Prevalence and Characteristics of Periodic Limb Movements during Sleep in Korean Adult Patients with Restless Legs Syndrome. Journal of Clinical Sleep Medicine, 12(8), 1089–1097. doi: 10.5664/jcsm.6042
Type
Article
ISSN
1550-9389
DOI
10.5664/jcsm.6042
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32450
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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