계명대학교 의학도서관 Repository

Could adjuvant chemotherapy after surgery benefit elderly patients with advanced gastric cancer?

Metadata Downloads
Author(s)
Jin Woon JeongIn Gyu KwonYoung-Gil SonSeung Wan Ryu
Keimyung Author(s)
Son, Young GilKwon, In GyuRyu, Seung Wan
Department
Dept. of Surgery (외과학)
Journal Title
Journal of Gastric Cancer
Issued Date
2016
Volume
16
Issue
4
Keyword
AgedChemotherapyAdjuvantGastrectomyStomach neoplasms
Abstract
Purpose: The aim of this study was to evaluate tolerance to adjuvant chemotherapy, and to compare survival between treatments using
only surgery and using surgery with adjuvant chemotherapy, in elderly patients with advanced gastric cancer who were ≥75 years of
age.
Materials and Methods: Patients ≥75 years of age who were diagnosed with pathological stage II or III gastric cancer were identified
retrospectively and categorized into the surgery only and surgery with adjuvant chemotherapy groups. Clinicopathological and survival
data were compared between these two groups.
Results: Among the 130 patients studied, 67 patients underwent curative surgery only, and 63 patients received adjuvant chemotherapy
after curative surgery. In the latter group, adverse events were reported in 24 patients (38.1%). The treatments were discontinued
in 19 patients (30.2%) owing to any reason. The overall 5-year survival rates of the surgery only and the surgery with adjuvant chemotherapy
groups did not differ significantly (44.1% vs. 30.7%, respectively; P=0.804). Among 90 death events, deaths from recurrences
of gastric cancer occurred in 42 patients. Multivariate analyses revealed that the American Society of Anesthesiologists score and the
depths of tumor invasions were related to survival, and the addition of adjuvant chemotherapy after surgery did not influence survival.
Conclusions: The decision for the addition of adjuvant chemotherapy for elderly patients should be taken after considering the condition
of individual patients and their life expectancies.
Keimyung Author(s)(Kor)
손영길
권인규
류승완
Publisher
School of Medicine
Citation
Jin Woon Jeong et al. (2016). Could adjuvant chemotherapy after surgery benefit elderly patients with advanced gastric cancer? Journal of Gastric Cancer, 16(4), 260–265. doi: 10.5230/jgc.2016.16.4.260
Type
Article
ISSN
2093-582X
DOI
10.5230/jgc.2016.16.4.260
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32453
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.