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Mood Symptoms and Restless Legs Syndrome Without Periodic Limb Movements During Sleep: Is it a Clinical Subtype?

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Author(s)
Hochang B. LeeMei Ling SongBrian B. KooYong Won Cho
Keimyung Author(s)
Cho, Yong Won
Department
Dept. of Neurology (신경과학)
Journal Title
Journal of Neuropsychiatry and Clinical Neurosciences
Issued Date
2016
Volume
29
Issue
1
Abstract
Frequently co-occurring restless legs syndrome (RLS) and periodic limb movements during sleep (PLMS) are postulated to share common pathophysiology. The authors compared clinical characteristics and polysomnography (PSG) parameters among 155 idiopathic, untreated RLS patients who were stratified into three groups based on periodic limb movement index (PLMI). The authors found that RLS patients without PLMS (PLMI <5) had higher depression and anxiety scores, a lower total arousal index, longer latency to REM, and a higher spontaneous arousal frequency on PSG than RLS patients with PLMS. RLS severity was associated with PLMI in RLS patients with PLMS but not without PLMS. RLS without PLMS seems to be a phenotypically distinct clinical subtype of RLS. Future study should examine whether RLS without PLMS has a different clinical course, treatment response, and pathophysiology than RLS with PLMS.
Keimyung Author(s)(Kor)
조용원
Publisher
School of Medicine
Citation
Hochang B. Lee et al. (2016). Mood Symptoms and Restless Legs Syndrome Without Periodic Limb Movements During Sleep: Is it a Clinical Subtype? Journal of Neuropsychiatry and Clinical Neurosciences, 29(1), 52–59. doi: 10.1176/appi.neuropsych.15090228
Type
Article
ISSN
0895-0172
DOI
10.1176/appi.neuropsych.15090228
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32474
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
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