계명대학교 의학도서관 Repository

18F-FDG PET/CT Can Predict Survival of Advanced Hepatocellular Carcinoma Patients: A Multicenter Retrospective Cohort Study

Metadata Downloads
Author(s)
Sae Jung NaJin Kyoung OhJeong Won LeeIl Ki HongBong-Il SongTae-Sung KimJae Seon EoSung Won LeeIe Ryung YooYong An ChungMijin YunSeung Hyup Hyun
Keimyung Author(s)
Song, Bong Il
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
Journal of Nuclear Medicine
Issued Date
2017
Volume
58
Issue
5
Keyword
hepatocellular carcinoma18F-FDGPET/CTsurvivalprognosis
Abstract
Barcelona Clinic Liver Cancer (BCLC) stage C hepatocellular carcinoma (HCC) consists of a heterogeneous group of patients with a wide range of survival times, requiring further prognostic stratification to facilitate treatment allocation. We evaluated the prognostic value of 18F-FDG uptake on PET/CT at the time of presentation in patients with BCLC stage C HCC. Methods: A total of 291 patients with BCLC stage C HCC who underwent 18F-FDG PET/CT between 2009 and 2010 for staging were retrospectively enrolled from 7 university hospitals. The patients were further divided into 2 groups according to the extent of disease, as intrahepatic or extrahepatic. Tumor-to-liver SUV ratio (TLR) of the primary tumor was measured on 18F-FDG PET/CT. Prognostic values of TLR and other clinical variables were analyzed to predict overall survival (OS) in univariate and multivariate analyses. Differences in the OS stratified by TLR were examined by the Kaplan–Meier method. Results: Higher TLR was associated with extrahepatic disease (P = 0.018). On multivariate analysis, Child–Pugh classification and TLR were independent prognostic factors in the intrahepatic disease group (all P < 0.05), whereas TLR was the only independent prognostic factor in the extrahepatic disease group (P < 0.05). Patients with high TLR showed a significantly worse OS than those with low TLR (P < 0.05) in both groups. Conclusion: In patients with BCLC stage C HCC, 18F-FDG uptake in the primary tumor was significantly higher in patients with extrahepatic disease than in those with intrahepatic disease. In addition, 18F-FDG uptake on pretreatment PET/CT had an incremental prognostic value for OS in both intrahepatic and extrahepatic disease groups.
Keimyung Author(s)(Kor)
송봉일
Publisher
School of Medicine
Citation
Sae Jung Na et al. (2017). 18F-FDG PET/CT Can Predict Survival of Advanced Hepatocellular Carcinoma Patients: A Multicenter Retrospective Cohort Study. Journal of Nuclear Medicine, 58(5), 730–736. doi: 10.2967/jnumed.116.182022
Type
Article
ISSN
0161-5505
DOI
10.2967/jnumed.116.182022
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32475
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.