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Risk factors associated with provoked pulmonary embolism

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Author(s)
Endri GjonbratajJi Na KimJuarda GjonbratajHye In JungHyun Jung KimWon-Il Choi
Keimyung Author(s)
Choi, Won IlKim, Hyun Jung
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Jouranl of Internal Medicine
Issued Date
2017
Volume
32
Issue
1
Keyword
CoagulationInfectionProtein SProvokedPulmonary embolism
Abstract
Background/Aims: This study aimed to investigate the risk factors associated
with provoked pulmonary embolism (PE).
Methods: This retrospective cohort study included 237 patients with PE. Patients
that had transient risk factors
at diagnosis were classified as having provoked PE,
with the remaining patients being classified as having unprovoked PE. The baseline
clinical characteristics and factors associated with coagulation were compared.
We evaluated the risk factors associated with provoked PE.
Results: Of the 237 PE patients, 73 (30.8%) had provoked PE. The rate of respiratory
failure and infection, as well as the disseminated intravascular coagulation
score and ratio of right ventricular diameter to left ventricular diameter were
significantly
higher in patients with provoked PE than in those with unprovoked
PE. The protein and activity levels associated with coagulation,
including protein
C antigen, protein S antigen, protein S activity, anti-thrombin III antigen, and
factor VIII, were significantly lower in patients with provoked PE than in those
with unprovoked PE. Multivariate analysis showed that infection (odds ratio [OR],
3.2; 95% confidence interval [CI], 1.4 to 7.4) and protein S activity (OR, 0.97; 95%
CI, 0.95 to 0.99) were significantly associated with provoked PE.
Conclusions: Protein S activity and presence of infection were important factors
associated with provoked PE. We should pay attention to the presence of infection
in patients with provoked PE.
Keimyung Author(s)(Kor)
최원일
김현정
Publisher
School of Medicine
Citation
Endri Gjonbrataj et al. (2017). Risk factors associated with provoked pulmonary embolism. Korean Jouranl of Internal Medicine, 32(1), 95–101. doi: 10.3904/kjim.2015.118
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2015.118
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32503
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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