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Association of biofilm production with colonization aming clinical isolates of Acinetobacer baumannii

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Author(s)
Seong Yeol RyuWon-Ki BaekHyun Ah Kim
Keimyung Author(s)
Ryu, Seong YeolKim, Hyun AhBaek, Won Ki
Department
Dept. of Internal Medicine (내과학)
Dept. of Microbiology (미생물학)
Journal Title
Korean Jouranl of Internal Medicine
Issued Date
2017
Volume
32
Issue
2
Keyword
Acinetobacter baumanniiBiofilmsCross infection
Abstract
Background/Aims: The pathogen Acinetobacter baumannii is increasingly causing
healthcare-associated infections worldwide, particularly in intensive care units.
Biofilm formation, a factor contributing to the virulence of A. baumannii, is associated
with long-term persistence in hospital environments. The present study
investigates the clinical impact of biofilm production on colonization and acquisition
after patient admission.
Methods: Forty-nine A. baumannii isolates were obtained between August and
November 2013 from Keimyung University Dongsan Medical Center, Daegu, Korea.
All isolates were obtained from sputum samples of new patients infected or
colonized by A. baumannii. The microtiter plate assay was used to determine biofilm
formation.
Results: Twenty-four A. baumannii isolates (48%) demonstrated enhanced biofilm
formation capacity than that of the standard A. baumannii strain (ATCC 19606).
All isolates were resistant to carbapenem, 38 isolates (77%) were collected from
patients in an intensive care unit, and 47 isolates (95%) were from patients who
had been exposed to antibiotics in the previous month. The median duration of
colonization was longer for biofilm-producing isolates than that of the biofilm
non-biofilm producing isolates (18 days vs. 12 days, p < 0.05). Simultaneous colonization
with other bacteria was more common for biofilm-producing isolates
than that for the non-biofilm producing isolates. The most prevalent co-colonizing
bacteria was Staphylococcus aureus.
Conclusions: Biofilm-producing isolates seem to colonize the respiratory tract
for longer durations than the non-biofilm producing isolates. During colonization,
biofilm producers promote co-colonization by other bacteria, particularly S.
aureus. Additional research is required to determine possible links between biofilm
formation and nosocomial infection.
Keimyung Author(s)(Kor)
류성열
김현아
백원기
Publisher
School of Medicine
Citation
Seong Yeol Ryu et al. (2017). Association of biofilm production with colonization aming clinical isolates of Acinetobacer baumannii. Korean Jouranl of Internal Medicine, 32(2), 345–351. doi: 10.3904/kjim.2015.287
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2015.287
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32507
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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