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Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study

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Author(s)
Myunghwan LeeTaegeon KwonSujin KimSaeyoung KimKibum ParkYounghoon Jeon
Keimyung Author(s)
Park, Ki Bum
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Medicine
Issued Date
2017
Volume
96
Issue
10
Keyword
esmololpainpropofolremifentanilinjectionintravenous
Abstract
Background:

Propofol is associated with pain during injection, which is stressful to patients. The present study was designed to investigate the analgesic effect of pretreatment with remifentanil and esmolol in minimizing propofol injection pain, compared with placebo.


Methods:

In a randomized, double-blind, prospective trial, 120 patients, scheduled for elective dental surgery under general anesthesia, were randomized to 1 of the 4 treatment arms (n = 30 each) receiving normal saline, remifentanil 0.35 μg/kg, esmolol 0.5 mg/kg, and 1 mg/kg before administration of propofol. During injection of 1% propofol 0.5 mg/kg, pain was evaluated by a 4-point score (0 = none, 1 = mild, 2 = moderate, 3 = severe). Any adverse effects such as hypotension and bradycardia were recorded during the perioperative periods.


Results:

In all, 120 patients completed this study. There were no significant differences in terms of demographic data. The incidence of pain on injection of propofol was 11 (36.7%) with remifentanil 0.35 μg/kg, 12 (40%) with esmolol 0.5 mg/kg, and 11 (36.7%) with esmolol 1 mg/kg, compared with 25 (83.3%) with normal saline (respectively, P < 0.05). There were no significant differences in the incidence of pain between groups with remifentanil 0.35 μg/kg, and esmolol 0.5 mg/kg and 1 mg/kg. There were no emergence reactions such as hypotension and bradycardia in all groups.


Conclusions:

Pretreatment with esmolol 0.5 mg/kg and 1 mg/kg and remifentanil 0.35 μg/kg equally decreased pain during propofol injection.
Keimyung Author(s)(Kor)
박기범
Publisher
School of Medicine
Citation
Myunghwan Lee et al. (2017). Comparative evaluation of the effect of remifentanil and 2 different doses of esmolol on pain during propofol injection: A double-blind, randomized clinical consort study. Medicine, 96(10), e6288–e6288. doi: 10.1097/MD.0000000000006288
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000006288
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32519
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
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