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relationaship between postural instability and subcortical volume loss in Alzheimer's disease

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Affiliated Author(s)
정인성이형이현아
Alternative Author(s)
Chung, In SungLee, HyungYi, Hyon Ah
Journal Title
Medicine
ISSN
0025-7974
Issued Date
2017
Keyword
Alzheimer's disease
Abstract
The relationship between postural instability and subcortical structure in AD has received less attention. The aims of this study were to assess whether there are differences in the ability to control balance between Alzheimer's disease (AD) and controls, and to investigate the association between subcortical gray matter volumes and postural instability in AD.

We enrolled 107 consecutive AD patients and 37 controls. All participants underwent detailed neuropsychological evaluations, T1-weighted MRI at 3 T, and posture assessment using computerized dynamic posturography. We segmented the volumes of 6 subcortical structures of the amygdala, thalamus, caudate nucleus, putamen, globus pallidus and nucleus accumbens, and of hippocampus, using the FMRIBs integrated registration and segmentation tool.

All subcortical structures, except for the globus pallidus, were smaller in AD compared with controls on adjusting for age and gender. Falling frequencies in unilateral stance test (UST) and composite scores in sensory organization test (SOT) were worse in AD than in controls. The motor control test did not reveal any differences between groups. On subgroup analyses in AD, the groups with poor performance in UST or SOT exhibited significantly reduced nucleus accumbens and putamen volumes, and nucleus accumbens volume, respectively. The smaller volume of the nucleus accumbens was associated with postural instability in AD (OR [95% CI] 17.847 [2.59–122.80] for UST, 42.827[6.06–302.47] for SOT, all P < .05).

AD patients exhibited reduced ability to control balance compared with controls, and this postural instability was associated with nucleus accumbens volume loss. Furthermore, cognitive dysfunction was more prominent in the group with severe postural instability.
Department
Dept. of Preventive Medicine (예방의학)
Dept. of Neurology (신경과학)
Brain Research Institute (뇌연구소)
Publisher
School of Medicine
Citation
Young-Wook Lee et al. (2017). relationaship between postural instability and subcortical volume loss in Alzheimer's disease. Medicine, 96(25), e7286–e7286. doi: 10.1097/MD.0000000000007286
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000007286
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32522
Appears in Collections:
3. Research Institutues (연구소) > Brain Research Institute (뇌연구소)
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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