계명대학교 의학도서관 Repository

Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma.

Metadata Downloads
Author(s)
Hye Won LeeTae In ParkSe Young JangSoo Young ParkWon-Jin ParkSoo-Jung JungJae-Ho Lee
Keimyung Author(s)
Lee, Jae Ho
Department
Dept. of Anatomy (해부학)
Journal Title
Medicine
Issued Date
2017
Volume
96
Issue
5
Keyword
HCCprognosistelomere lengthTERT promoter mutation
Abstract
Promoter mutations in telomerase reverse transcriptase (TERT) and telomere length have been studied in various tumors. In the present study, the frequency and clinical characteristics of TERT promoter mutation and telomere length were studied in hepatocellular carcinoma (HCC). TERT promoter mutation and telomere length were analyzed in 162 tumor samples of the patients with HCC by sequencing and real-time PCR, respectively. The TERT promoter mutation rate was 28.8% (46/160) in HCC and was associated with males (P = 0.027). The telomere length was not significantly different in the presence of a TERT promoter mutation but was shorter in high-grade tumor stages (P = 0.048). Survival analyses showed that poor overall survival was associated with longer telomere length (P = 0.013). However, the TERT promoter mutation did not have a prognostic value for HCC. Multivariate survival analyses demonstrated that the telomere length was an independent prognostic marker for poor overall survival (hazard ratio = 1.75, 95% confidence interval: 1.046–2.913, P = 0.033). These data demonstrated that TERT promoter mutation is a frequent event in HCC; however, telomere length, but not the presence of a TERT promoter mutation, might have potential value as a prognostic indicator of HCC.
Keimyung Author(s)(Kor)
이재호
Publisher
School of Medicine
Citation
Hye Won Lee et al. (2017). Clinicopathological characteristics of TERT promoter mutation and telomere length in hepatocellular carcinoma. Medicine, 96(5), e5766–e5766. doi: 10.1097/MD.0000000000005766
Type
Article
ISSN
0025-7974
DOI
10.1097/MD.0000000000005766
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32525
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
공개 및 라이선스
  • 공개 구분공개
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.