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Etiologic characteristics and index pregnancy outcomes of recurrent pregnancy losses in Korean women

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Author(s)
Gi Su LeeJoon Cheol ParkJeong Ho RheeJong In Kim
Keimyung Author(s)
Park, Joon CheolKim, Jong InRhee, Jeong Ho
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Obstetrics & Gynecology Science
Issued Date
2016
Volume
59
Issue
5
Keyword
Clinical outcomesEtiologyRecurrent pregnancy
Abstract
Objective;
The goal of this study was to evaluate the etiologies and clinical outcomes of Korean recurrent pregnancy loss (RPL)
patients. And also, we investigated the differences between primary and secondary RPL patients, between two and
three or more pregnancy losses.
Methods;
One hundred seventy eight women diagnosed as RPL were enrolled. We performed chromosomal analysis, thyroid
stimulating hormone, prolactin, blood glucose, plasminogen activator inhibitor-1, natural killer cell proportion,
anticardiolipin antibodies, antiphospholipid antibodies, lupus anticoagulant, anti-β2glycoprotein-1 antibodies,
antinuclear antibody, protein C, protein S, antithrombin III, homocysteine, MTFHR gene, factor V Leiden mutation, and
hysterosalphingography/hysteroscopic evaluation.
Results;
The mean age was 34.03±4.30 years, and mean number of miscarriages was 2.69±1.11 (range, 2 to 11). Anatomical
cause (13.5%), chromosomal abnormalities (5.6%), and endocrine disorders (34.3%) were observed in RPL women.
Elevated natural killer cell and antiphospholipid antibodies were observed in 43.3% and 7.3% each. Among of
178 women, 77 women were pregnant. After management of those women, live birth rate was 84.4% and mean
gestational weeks was 37.63±5.12. Women with three or more RPL compared with women with two RPL had more
common anatomical cause such as intrauterine adhesions and lower rates of spontaneous pregnancy. Compare with
secondary RPL women, immunological abnormalities were more common in primary RPL. However, miscarriage rates
were not different.
Conclusion;
Immunological factor including autoimmune and alloimmune disorders was most common etiology of RPL. Inherited
thrombophilia showed different patterns with other ethnic countries. Miscarriage rates were not different between
primary and secondary RPL, or between two and three or more miscarriages group
Keimyung Author(s)(Kor)
김종인
이정호
박준철
Publisher
School of Medicine
Citation
Gi Su Lee et al. (2016). Etiologic characteristics and index pregnancy outcomes of recurrent pregnancy losses in Korean women. Obstetrics & Gynecology Science, 59(5), 379–387. doi: 10.5468/ogs.2016.59.5.379
Type
Article
ISSN
2287-8572
DOI
10.5468/ogs.2016.59.5.379
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32534
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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