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Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: Results of a multicenter prospective cohort study.

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Author(s)
Jun Sik HongMyung Hee ChangJeong-A KimJae-Yong KwakJin Seok KimDok Hyun YoonWon Sik LeeYoung Rok DoHye Jin KangHyeon-Seok EomYong ParkJong-Ho WonYeung-Chul MunHyo Jung KimJung Hye KwonJee Hyun KongSung Yong OhSunah LeeSung Hwa BaeDeok-Hwan YangHyun Jung JunYang Soo KimHwan Jung YunSoon Il LeeMin Kyoung KimEun Kyung ParkWon Seog KimCheolwon SuhSeok Jin Kim
Keimyung Author(s)
Do, Young Rok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Oncotarget
Issued Date
2016
Volume
7
Issue
44
Keyword
diffuse large B-cell lymphomacentral nervous systemprognosislactate dehydrogenase
Abstract
Central nervous system involvement remains a challenging issue in the treatment of patients with diffuse large B-cell lymphoma. We conducted a prospective cohort study with newly diagnosed diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone to identify incidence and risk factors for central nervous system involvement. Among 595 patients, 279 patients received pre-treatment central nervous system evaluation, and 14 patients had central nervous system involvement at diagnosis (2.3% out of entire patients and 5.0% out of the 279 patients). For those patients, median follow-up duration was 38.2 months and some of them achieved long-term survival. Out of 581 patients who did not have central nervous system involvement at diagnosis, 26 patients underwent secondary central nervous system relapse with a median follow-up of 35 months, and the median time to central nervous system involvement was 10.4 months (range: 3.4–29.2). Serum lactate dehydrogenase > ×3 upper limit of normal range, the Eastern Cooperative Oncology Group performance status ≥ 2, and involvement of sinonasal tract or testis, were independent risk factors for central nervous system relapse in multivariate analysis. Our study suggests that enhanced stratification of serum lactate dehydrogenase according to the National Comprehensive Cancer Network-International Prognostic Index may contribute to better prediction for central nervous system relapse in patients with diffuse large B-cell lymphoma. This trial was registered at clinicaltrials.gov identifier: 01202448.
Keimyung Author(s)(Kor)
도영록
Publisher
School of Medicine
Citation
Jun Sik Hong et al. (2016). Highly elevated serum lactate dehydrogenase is associated with central nervous system relapse in patients with diffuse large B-cell lymphoma: Results of a multicenter prospective cohort study. Oncotarget, 7(44), 72033–72043. doi: 10.18632/oncotarget.12459
Type
Article
ISSN
1949-2553
DOI
10.18632/oncotarget.12459
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32539
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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