The Significance of Serum HER2 Levels at Diagnosis on Intrinsic Subtype-Specific Outcome of Operable Breast Cancer Patients
- Author(s)
- Moo Hyun Lee; So-Youn Jung; Sun Hee Kang; Eun Jin Song; In Hae Park; Young Mee Kwon; Keun Seok Lee; Han-Sung Kang; Eun Sook Lee; Sun-Young Kong
- Keimyung Author(s)
- Lee, Moo Hyun; Kang, Sun Hee
- Department
- Dept. of Surgery (외과학)
- Journal Title
- PloS One
- Issued Date
- 2016
- Volume
- 11
- Issue
- 10
- Abstract
- Purpose;
This study evaluated the association of serum HER2 (sHER2) levels at diagnosis with clinicopathologic
parameters and disease free survival (DFS) in operable breast cancer
patients according to intrinsic subtype.
Results;
There were 436 consecutive stage I-III breast cancer patients with sHER2 result at diagnosis
between Nov 2004 and Dec 2011. High sHER2 levels ( 15 ng/ml) were reported in 52
patients (11.9%) and HER2 overexpression in tumor tissue was observed in 111 patients
(25.5%). High sHER2 levels were associated significantly with advanced stage (P < 0.001),
mastectomy (P = 0.012), neoadjuvant chemotherapy (P < 0.001), anti-HER2 therapy
(P < 0.001) and hormone therapy (P = 0.022). The patients with high sHER2 levels had a
worse DFS (P < 0.001). In multivariate analysis, high sHER2 levels were associated significantly
with worse DFS (HR = 2.25, 95% CI 1.27±3.99, P = 0.005). High sHER2 levels were
associated with worse DFS in the HR+/HER2-, HR+/HER2+ and HR-/HER2+ subtypes
(P = 0.043, 0.003 and 0.041, respectively).
Methods;
The sHER2 levels were measured using a chemiluminescence immunoassay. The HER2
status in all tumor tissues was determined by immunohistochemistry, and confirmed in
equivocal cases by fluorescence in situ. Conclusions;
These results show that the sHER2 level at diagnosis is a useful prognostic factor in
patients with operable breast cancer, especially in the HR+/HER2-, HR+/HER2+ and HR-/
HER2+ subtypes.
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