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Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial

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Author(s)
Tae Ho KimJae Seung ChangKyu-Sang ParkJeeyeon ParkNahyun KimJong In LeeIn Deok Kong
Keimyung Author(s)
Kim, Na Hyun
Department
Dept. of Nursing (간호학)
Journal Title
PloS One
Issued Date
2017
Volume
12
Issue
2
Abstract
Background;

Wingless and integration site growth factor (Wnt) signaling is a tumorigenesis-related signaling pathway. Dickkpof-1 (DKK1) and secreted frizzled-related protein-1 (SFRP1) are endogenous negative regulators of Wnt/β-catenin signaling. Accumulating evidence indicates that higher serum levels of DKK1 are correlated with poor prognosis of various types of cancer. Here, we investigated whether exercise training causes changes in the serum levels of DKK1 and SFRP1 in patients with breast cancer.


Methods;

Twenty-four breast cancer survivors, after chemo- or radiotherapy, participated in this single-blind randomized, controlled pilot study. Subjects were randomized to either an exercise program or a control group for 12 weeks and completed pre- and post-training tests for health-related fitness and body composition as well as blood biomarkers. The serum levels of DKK1 and SFRP1 were measured using enzyme-linked immunosorbent assay as the primary outcome.


Results;

Exercise training for 12 weeks remarkably increased muscle strength, endurance, and flexibility and decreased body fat percentage, waist circumference, and visceral fat area (all p < 0.05). Exercise training lowered serum insulin levels and leptin/adiponectin ratios (all p < 0.05). The levels of DKK1 and SFRP1 were also significantly decreased by exercise training in breast cancer survivors (all p < 0.01).


Conclusions;

Our results indicate that DKK1 and SFRP1 may be potentially useful biomarkers for evaluating the beneficial effects of long-term exercise on physical fitness and metabolism as well as the prognosis of patients with cancer.
Keimyung Author(s)(Kor)
김나현
Publisher
College of Nursing
Citation
Tae Ho Kim et al. (2017). Effects of exercise training on circulating levels of Dickkpof-1 and secreted frizzled-related protein-1 in breast cancer survivors: A pilot single-blind randomized controlled trial. PloS One, 12(2), e0171771–e0171771. doi: 10.1371/journal.pone.0171771
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0171771
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32551
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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