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Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models

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Author(s)
Sun Ha LimYaesil KimKi Na YunJin Young KimJung-Hee JangMee-Jung HanJongwon Lee
Keimyung Author(s)
Jang, Jung Hee
Department
Dept. of Pharmacology (약리학)
Journal Title
Scientific Reports
Issued Date
2016
Volume
6
Abstract
Many cohort studies have shown that consumption of diets containing a higher composition of foods derived from plants reduces mortality from coronary heart disease (CHD). Here, we examined the active components of a plant-based diet and the underlying mechanisms that reduce the risk of CHD using three rat models and a quantitative proteomics approach. In a short-term myocardial infarction (MI) model, intake of wheat extract (WE), the representative cardioprotectant identified by screening approximately 4,000 samples, reduced myocardial injury by inhibiting apoptosis, enhancing ATP production, and maintaining protein homeostasis. In long-term post-MI models, this myocardial protection resulted in ameliorating adverse left-ventricular remodelling, which is a predictor of heart failure. Among the wheat components, arabinose and xylose were identified as active components responsible for the observed efficacy of WE, which was administered via ingestion and tail-vein injections. Finally, the food components of plant-based diets that contained cell wall polysaccharides rich in arabinose, xylose, and possibly fucose were found to confer protection against myocardial injury. These results show for the first time that specific monosaccharides found in the cell wall polysaccharides in plant-based diets can act as active ingredients that reduce CHD by inhibiting postocclusion steps, including MI and heart failure.
Keimyung Author(s)(Kor)
장정희
Publisher
School of Medicine
Citation
Sun Ha Lim et al. (2016). Plant-based foods containing cell wall polysaccharides rich in specific active monosaccharides protect against myocardial injury in rat myocardial infarction models. Scientific Reports, 6, 38728–38728. doi: 10.1038/srep38728
Type
Article
ISSN
0068-1261
DOI
10.1038/srep38728
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32564
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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