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High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17.

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Author(s)
Jee In Kim
Keimyung Author(s)
Kim, Jee In
Department
Dept. of Molecular Medicine (분자의학)
Journal Title
korean Journal of Physiology & Pharmacology
Issued Date
2017
Volume
21
Issue
1
Keyword
Angiontensin IICPI-17HypertensionMLCKObesity
Abstract
Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the underlying mechanism for increased vascular tone and consequent increase in blood pressure (BP) is largely unknown. The purpose of this study is to investigate the novel mechanism underlying Ang II-induced hyper-contractility and hypertension in obese rats. Eight-week old male Sprague-Dawley rats were fed with 60% fat diet or normal diet for 4 months. Body weight, plasma lipid profile, plasma Ang II level, BP, Ang II-induced vascular contraction, and expression of regulatory proteins modulating vascular contraction with/without Ang II stimulation were measured. As a result, high fat diet (HFD) accelerated age-dependent body weight gaining along with increased plasma Ang II concentration. It also increased BP and Ang II-induced aortic contraction. Basal expression of p-CPI-17 and myosin light chain (MLC) kinase was increased by HFD along with increased phosphorylation of MLC. Ang II-induced phosphorylation of CPI-17 and MLC were also higher in HFD group than control group. In conclusion HFD-induced hypertension is through at least in part by increased vascular contractility via increased expression and activation of contractile proteins and subsequent MLC phosphorylation induced by increased Ang II.
Keimyung Author(s)(Kor)
김지인
Publisher
School of Medicine
Citation
Jee In Kim. (2017). High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17. korean Journal of Physiology & Pharmacology, 21(1), 99–106. doi: 10.4196/kjpp.2017.21.1.99
Type
Article
ISSN
1226-4512
DOI
10.4196/kjpp.2017.21.1.99
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32576
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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