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Absence of GNAS mutation in colorectal carcinogenesis

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Author(s)
Hyungsu LeeBoo-Mi LaIlSeon HwangYu-Na KangIn-Jang ChoiJae-Ho Lee
Keimyung Author(s)
Choi, In JangHwang, Il SeonLee, Jae HoKang, Yu NaLee, Hyun Su
Department
Dept. of Pathology (병리학)
Dept. of Anatomy (해부학)
Journal Title
Tumori
Issued Date
2017
Volume
103
Issue
2
Keyword
Colorectal cancerGNASHyperplastic polypsSessile serrated adenomasTubular adenomaVillous adenoma
Abstract
Aims and background;
The incidence rate of colorectal cancer (CRC) increases every year in Korean populations. However, association between the GNAS mutation and colorectal precancerous lesions has not been studied in in Korean populations. To contribute to better understanding of colorectal carcinogenesis, we analyzed GNAS mutation in 100 cancerous and 96 precancerous colorectal lesions.
Methods;
The records of colonoscopic polypectomy performed at Dongsan Medical Center between 1999 and 2003 were reviewed retrospectively. Precancerous lesions included 7 villous adenomas, 59 tubular adenomas, and 18 sessile serrated adenomas, and 12 hyperplastic polyps. Keimyung Human Bio-Resource Bank at Dongsan Medical Center provided 100 CRC samples.
Results;
GNAS mutation was not found in any colorectal cancer or any precancerous colorectal lesions, including villous adenoma, which is thought to harbor the mutation.
Conclusions;
The role of GNAS mutation might be limited in colorectal neoplasms of the Korean population.
Keimyung Author(s)(Kor)
최인장
강유나
황일선
이현수
이재호
Publisher
School of Medicine
Citation
Hyungsu Lee et al. (2017). Absence of GNAS mutation in colorectal carcinogenesis. Tumori, 103(2), 209–211. doi: 10.5301/tj.5000400
Type
Article
ISSN
0300-8916
DOI
10.5301/tj.5000400
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32580
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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