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글라이포세이트의 유전자 독성에 대한 멜라토닌의 유전자 보호 효과

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Author(s)
김정규최우익이재호최인장진상찬
Keimyung Author(s)
Lee, Jae HoJin, Sang ChanChoi, Woo IkChoi, In Jang
Department
Dept. of Anatomy (해부학)
Dept. of Emergency Medicine (응급의학)
Journal Title
대한임상독성학회지
Issued Date
2016
Volume
14
Issue
2
Keyword
GlyphosateGenotoxicSister chromatid exchangeMelatonin
Abstract
Purpose: Glyphosate is a widely used non-selective herbicide. Previous studies have shown that glyphosate has genotoxicity,
and that even low-doses of glyphosate can cause DNA damage. Melatonin is a hormone produced and secreted
by the pineal gland that is known to be a potent anti-carcinogen, anti-oxidant, and genetic protector. This study was
conducted to investigate the genoprotective effect of melatonin against glyphosate in human blood lymphocytes.
Methods: Human peripheral blood was obtained from 15 young, healthy volunteers and cultured under four different
toxicologic conditions. The four groups consisted of a control group, glyphosate only group (300 ng/mL),
glyphosate with low level of melatonin group (50 μM), and glyphosate with high level of melatonin group (200 μM).
The mean Sister Chromatid Exchange (SCE) frequency of each group was then analyzed.
Results: Glyphosate exposed groups had a higher mean SCE frequency (10.33±2.50) than the control group (6.78
±2.31, p<0.001). Interestingly, the group that received a low-level of melatonin had a lower mean SCE frequency
(8.67±2.58) than the glyphosate-only group, while the group that received a high level of melatonin had a much
lower mean SCE frequency (8.06±2.50) than the glyphosate-only group. There was statistical significance.
Conclusion: Melatonin exerted a potent gene protective effect against the genotoxicity of glyphosate on human
blood lymphocytes in a dose-dependent fashion.
Alternative Title
Genoprotective Effect of Melatonin Against to the Genotoxicity of Glyphosate on Human Blood Lymphocytes
Keimyung Author(s)(Kor)
이재호
진상찬
최우익
최인장
Publisher
School of Medicine
Citation
김정규 et al. (2016). 글라이포세이트의 유전자 독성에 대한 멜라토닌의 유전자 보호 효과. 대한임상독성학회지, 14(2), 144–150. doi: 10.22537/jksct.14.2.144
Type
Article
ISSN
1738-1320
DOI
10.22537/jksct.14.2.144
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32629
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학)
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