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The potential of cystatin-C to evaluate the prognosis of acute heart failure

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Author(s)
Tae-Hun KimHyungseop KimIn-Cheol Kim
Keimyung Author(s)
Kim, In CheolKim, Hyung Seop
Department
Dept. of Internal Medicine (내과학)
Journal Title
Acute Cardiac Care
Issued Date
2015
Volume
17
Issue
4
Keyword
Cystatin-Curic acidNT-proBNPheart failure
Abstract
Background: The prognosis of acute heart failure (HF) can be determined by cardio-renal function which is assessed by cystatin-C (Cys-C). We evaluated whether Cys-C could be a more useful prognostic indicator in acute HF, compared with uric acid (UA) and N-terminal pro-B-type natriuretic peptide (NT-proBNP).

Methods: Two hundred thirty-two HF patients in the emergency room were studied using measurements of Cys-C, UA, and NT-proBNP. During the follow-up, cardiac events, defined as the composites of recurrent HF or cardiac death, were determined.

Results: Seventy-seven cardiac events (28 cardiac deaths, 49 recurrent HFs) occurred over two years. The events group revealed higher levels of Cys-C, UA, and NT-proBNP. They showed increased blood urea nitrogen and creatinine, reduced septal tissue Doppler velocity (TVI-Sm), and low frequencies of beta-blockers (BB), diuretics and angiotensin-converting enzyme inhibitors/-receptor blockers. Cys-C (the best cutoff: 1.7 mg/l) had a steady, persistent hazard ratio (HR) over two years. On multivariate analysis, Cys-C, TVI-Sm, and BB were significant predictors for adverse events. Cys-C provided an incremental value for prognosis more than NT-proBNP and UA did over the follow-up period.

Conclusions: Compared with UA and NT-proBNP, Cys-C could be better prognostic biomarker for cardiac events two years after acute HF.
Keimyung Author(s)(Kor)
김형섭
김인철
Publisher
School of Medicine
Citation
Tae-Hun Kim et al. (2015). The potential of cystatin-C to evaluate the prognosis of acute heart failure. Acute Cardiac Care, 17(4), 72–76. doi: 10.1080/17482941.2016.1203440
Type
Article
ISSN
1748-2941
Source
https://www.tandfonline.com/doi/full/10.1080/17482941.2016.1203440
DOI
10.1080/17482941.2016.1203440
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/32685
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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